UNM Cancer Center unveils groundbreaking CAR-T therapy for combating stubborn cancers

The University of New Mexico Comprehensive Cancer Center Launches CAR-T Therapy to Combat Multiple Refractory Cancers

Introduction

The University of New Mexico Comprehensive Cancer Center launched a new Chimeric Antigen Receptor T-Cell (CAR-T) therapy program to combat multiple refractory cancers such as lymphomas, myelomas, and leukemias. The CAR-T therapy program has shown promising results in patients who have not responded well to conventional treatments. This informative article will provide detailed information about the CAR-T therapy program, potential side effects, and how the patients can benefit from this innovative treatment program.

About CAR-T Therapy

Chimeric Antigen Receptor T-Cell (CAR-T) therapy is a revolutionary cancer treatment program that utilizes white blood cells to fight cancer cells. Dr. Shashank Cingam, a member of the UNM Cancer Center’s Bone Marrow Transplant and Cellular Therapy Team, explains that CAR-T therapy is akin to a bone marrow transplant but differs in its approach. Instead of stem cells, white blood cells are collected, which are then sent to an external lab where they are modified and multiplied to express receptors capable of detecting and destroying cancer cells. However, a mild chemotherapy regimen is necessary to weaken the immune system before the modified cells are reintroduced to the patient’s body. This process prevents the immune system from rejecting these reinforcements. Once injected, these CAR-T cells multiply in the body and attack the cancer cells directly. The response from CAR-T therapy can be swift, but the duration of therapy varies from person to person.

Benefits of CAR-T Therapy

CAR-T therapy provides several benefits to cancer patients. Firstly, it is an alternative treatment option for patients who have not responded well to conventional therapies. Secondly, CAR-T therapy can target specific cancer cells without affecting healthy cells, thus reducing the possibility of side effects. Lastly, the UNM Cancer Center’s Bone Marrow Transplant and Cellular Therapy program provides four different commercial CAR-T therapies targeting several types of lymphoma and multiple myeloma, thus offering personalized treatment to patients.

Potential Side Effects

Dr. Cingam emphasizes that CAR-T therapy is a living drug, which can result in potential side effects. The modified cells can multiply in the patient’s body and release inflammatory cytokines, leading to side effects such as high fever and brain inflammation that require close monitoring. Patients may need to receive steroids and other anti-inflammatory therapies to manage these side effects.

Impact of CAR-T Therapy at UNM Cancer Center

The UNM Comprehensive Cancer Center serves as New Mexico’s official cancer center and holds a National Cancer Institute designation within a 500-mile radius. It offers advanced care across numerous oncology fields through its extensive team of healthcare professionals. In addition to patient care, UNM Cancer Center engages in cutting-edge research funded by $38.2 million in grants and contracts since 2015 and contributes significantly to economic development through patents and biotech startups. Furthermore, it plays a crucial role in education by providing training opportunities for over 500 students annually.

Local Option for Patients

Currently, New Mexico patients often have to travel significant distances for CAR-T treatment due to the necessity of staying near medical facilities for extended periods post-procedure. However, the new program at the UNM Cancer Center offers a local option that reduces the travel burden for patients and their families. Patients can receive personalized care and treatment at the UNM Cancer Center without having to leave the state for treatment.

Clinical Trials

Clinical trials are also underway to explore further applications of the CAR-T therapy. UNM Center Director of the Bone Marrow and Stem Cell Transplant Program, Dr. Matthew Fero highlighted the effectiveness of CAR-T therapy and emphasized that it provides patients with another great treatment option.

Conclusion

The UNM Comprehensive Cancer Center’s new CAR-T therapy program provides a promising treatment option for patients who have not responded well to conventional cancer treatments such as chemotherapy and radiation therapy. Apart from its benefits, CAR-T therapy has potential side effects that require close monitoring. With the UNM Cancer Center’s Bone Marrow Transplant and Cellular Therapy program, patients can receive personalized treatment for several types of lymphoma and myeloma, reducing the need for long-distance travel for treatment. Clinical trials are currently underway to explore further applications of the CAR-T therapy.

Originally Post From https://newmexicosun.com/stories/661207530-unm-cancer-center-introduces-new-car-t-therapy-for-treating-resistant-cancers